Bryan J. Cowen

  • Biographical Description

    • Assistant Professor, Chemistry and Biochemistry

  • Education

    • Ph.D., Chemistry, Yale University, 2009

      Research Advisor: Professor Scott J. Miller

      B.S., Chemistry, Binghamton University, 2004

      Research Advisor: Professor Susan L. Bane

  • Professional Experience

    • Assistant Professor, Department of Chemistry and Biochemistry, University of Denver, 2012 - present

      NIH Postdoctoral Research Fellow, Memorial Sloan-Kettering Cancer Center, 2009 - 2012

      Research Advisor: Professor David Y. Gin 

  • Teaching - Autumn 2014

    • CHEM 2453 - Organic Chemistry III, Section 2

      Lecture: TR      8:00-9:30 am

      Recitation: W   8:00-8:50 am

      Location: Olin Hall 105

       

  • Research

    • The Cowen group's research program focuses on the development of new synthetic methods for the preparation of small, functional organic compounds. Special emphasis centers on the discovery of unique asymmetric reactions to enable the selective construction of complex chiral molecular architectures. The design of small-molecule catalysts and ligands for both non-metal and metal-mediated transformations are key research activities ongoing in the laboratory. Additionally, the investigation of detailed mechanistic reaction pathways is of paramount importance to the maturation of any new synthetic method. A particular goal of our efforts in chemical synthesis is to produce valuable end products for potential pharmaceutical or material-based applications.
  • Publications

    • Saunders, L. B.; Cowen, B. J.; Miller, S. J. “Pyridylalanine (Pal)-Peptide Catalyzed Enantioselective Allenoate Additions to N-Acyl Imines Proceed via an Atypical “aza-MoritaBaylisHillman" Mechanism” Org. Lett. 2010, 12, 4800-4803.

      Cowen, B. J.; Miller, S. J. “Enantioselective Catalysis and Complexity Generation from Allenoates” Chem. Soc. Rev. 2009, 38, 3102-3116.

      Cowen, B. J.; Saunders, L. B.; Miller, S. J. “Pyridylalanine (Pal)-Peptide Catalyzed Enantioselective Allenoate Additions to N-Acyl Imines” J. Am. Chem. Soc. 2009, 131, 6105-6107.

      Cowen, B. J.; Miller, S. J. “Enantioselective [3+2]-Cycloadditions Catalyzed by a Protected, Multifunctional Phosphine-Containing α-Amino Acid” J. Am. Chem. Soc. 2007, 129, 10988-10989.

      Evans, C. A.; Cowen, B. J.; Miller, S. J. “Diversity-Generation from an Allenoate-Enone Coupling: Syntheses of Azepines and Pyrimidones from Common Precursors” Tetrahedron 2005, 61, 6309-6314.

This portfolio last updated: Oct 22, 2014 3:16:52 PM