Brian W. Michel

Organic Synthesis, Catalysis, Fluorescent Probe Design

  • Research Overview

    • In the Michel group we have two general areas that we are interested in. The development of new synthetic methods and the design of probes for detecting small molecule analytes of biological relevance. Students in the group will benefit from the multidisciplinary nature of our group and will have the opprotunity to become exceptional scientist.

  • Probe Design

    • Biological systems present an incredibly complex environment that can make the study of a single analyte challenging. However, small molecule probes that provide a readout of the presence of a specific analyte can allow for the selective interogation of the analyte's biological function. To this end, our group will draw from our strong organic and organometallic expertise in developing highly selective and sensitive probes to detect challenging analytes.

      Students working in this area will learn: Organic and Organometallic Synthesis, Data Analysis, Structural Characterization, Optical Characterization, Microscopy, Chemical Biology, and Hypothesis Driven Design.

    • fluorescent vials.jpg
      fluorescent vials.jpg
  • New Synthetic Methods

    • Our group is interested in developing new synthetic methods that allow for the rapid functionalization and diversification of much simpler starting materials. To accomplish this we focus on understanding the underlying factors that control reactivity and selectivity. This mechanistic understanding allows us to make rational changes to reaction conditions and improve the reaction outcome.

      Students working in this area will learn: Organic and Organometallic Synthesis, Assay Development, Physical Organic Techniques, Data Analysis, Structural Characterization, and Hypothesis Driven Design.

    • Reaction

This portfolio last updated: 11-May-2018 10:34 AM